Mucosal Immunization Tolerance or Enhanced Priming Following ADP-Ribosylation Controls the Outcome of
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ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization.
Accumulating evidence suggests that the dichotomy between tolerance and active IgA immunity in mucosal immune responses is regulated at the APC level. Therefore, immunomodulation of the APC could be an effective mechanism to control the two response patterns. In this study, we demonstrate that ADP-ribosylation controls the outcome of tolerance or active effector T cell immunity to an internal p...
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تاریخ انتشار 2010